Introduction Head and neck squamous cell carcinoma (HNSCC) is a common

Introduction Head and neck squamous cell carcinoma (HNSCC) is a common tumor worldwide and includes a poor prognosis. 0.05 were considered in multivariate Cox and analysis proportional hazards models. A Org 27569 two-sided worth significantly less than 0.05 was considered significant. Outcomes Patient features The 194 entitled sufferers with levels I-IVb HNSCC got a median age group of 54?years (range 25C86?years); 150 had been men (Desk?1). From the 194 sufferers, 156 had dental malignancies, 11 got supraglottic malignancies, and 21 got glottic malignancies. Adjuvant radiotherapy was presented with to 34 (17.5%) sufferers. The median follow-up period was 79?a few months (range 3C168?a few months). Just 14 (7.2%) sufferers were shed to follow-up. By the final follow-up visit, 116 (59.8%) patients had local or distant relapse events. The disease-specific mortality was 41.8% (81/194). Table?1 Associations between T lymphoma invasion and metastasis 1 (Tiam1) expression and clinicopathologic characteristics of the 194 patients with head and neck squamous Org 27569 cell carcinoma (HNSCC) Cut-off score selection The ROC curve for the scores of Tiam1 expression was plotted to select the appropriate cut-off score (Fig.?1). The area under the curve was 0.692 [P?P?P?P?=?0.003), and stage III/IV cancers (P?P?=?0.064). Fig.?2 Tiam1 expression in tumor samples Mouse monoclonal to TEC and noncancerous tissue samples. Tiam1 protein staining mainly distributes in the cytoplasm. a (100) and b (200), strong staining of Tiam1 protein in tumor cells. c (100) and d (200), … Predictive value of the Tiam1 expression score The 1-, 3-, and 5-12 months OS rates of all patients were 91.8, 70.5, Org 27569 and 64.7%, respectively. The 1-, 3-, and 5-12 months DFS rates were 64.8%, 48.1%, 43.2%, respectively. The relapse rate was higher in the high Tiam1 expression group than in the low Tiam1 expression group (70.5% vs. 45.1%, P?P?P?