iASPP is an inhibitory member of apoptosis-stimulating proteins of p53 (ASPP) family, which inhibits p53-dependent apoptosis

iASPP is an inhibitory member of apoptosis-stimulating proteins of p53 (ASPP) family, which inhibits p53-dependent apoptosis. like to say thanks to Prof. Lu Xin (Ludwig Institute for Malignancy Study, Oxford, UK) to provide plasmid pcDNA3.1-WT-iASPP-V5. Abbreviations FHL2four and a half LIM domains 2ASPPapoptosis-stimulating proteins of p53iASPPinhibitory member of ASPP familyALacute leukemiaAMLacute myeloid leukemiaAML-M6acute erythroid leukemiaBMMNCsbone marrow mononuclear cellsCo-IPcoimmunoprecipitationL1/2-3the 1st 3 and a half LIM domainsSCRscramble sequenceshFHL2target sequence of FHL2 Contributed by Authors’ contributions W.L performed almost all experimental validation, statistical data analysis and wrote the manuscript; T.Y, S.L, S.L, S.L, and J.L helped with experimental validation and statistical data analysis; Y.X, H.X, Z.T, and K.T assisted in molecular studies and plasmid building; Rabbit polyclonal to ANXA8L2 Q.R proposed constructive suggestions about the study; J.W and M. W designed the study, interpreted data, revised and authorized the manuscript. All authors go through and authorized the final manuscript. CONFLICTS OF INTEREST The authors declare no conflicts interests. 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