To research the clinical outcome of the Trabectome in Chinese open-angle glaucoma (OAG). main open-angle glaucoma and 5.3% had a history of chronic angle-closure glaucoma with open-angles after cataract extraction. The subjects’ mean age was 67.5?±?14.4 years with 4 females and 15 males. Two individuals required secondary filtration process. At GSK-923295 6 months the IOP reduced by 34.8% (24.4?±?4.4?mm Hg to 15.9?±?5.1?mm Hg P?0.0001). The number of types of antiglaucoma medications was reduced by 28.2% (3.9?±?0.8-2.8?±?1.6 P?0.0001). The TIE1 visual acuity was static at 1 GSK-923295 and 6 months postoperatively (P?=?0.4). There were no intraoperative complications. 26.3% of subjects had a transient IOP spike?>?21?mm Hg 1 had hyphema requiring washout and 1 had reactivation of herpetic keratitis. The success rate at 6 months was 89.5%. Trabectome achieved a modest reduction in IOP and medications in the majority of pseudophakic Chinese OAG eyes. INTRODUCTION In the past decade or so there have been many developments in minimally invasive glaucoma surgeries in the hope to minimize complications from traditional filtration surgeries while achieving a reasonable amount of intraocular pressure (IOP) lowering. The Trabectome is a surgical device approved for use by the Food and Drug Administration in 2004. It uses an electrical probe placed through a 1.8?mm clear corneal incision to reestablish the outflow of aqueous by stripping the trabecular meshwork and the inner wall of the Schlemm canal.1 2 GSK-923295 The Trabectome can be done as a stand-alone procedure or in combination with cataract extraction or other glaucoma surgeries. In a retrospective case series involving 1127 Trabectome cases the mean IOP reduction was approximately 39% and antiglaucoma medication reduction was around 57% at 24 months. However about 34.5% of the reported Trabectome cases were combined with other procedures and not just GSK-923295 the Trabectome procedure alone. The patient demographics were also predominantly Caucasian or Hispanics with only 3.5% of the patients being of Asian ethnicity.3 The aim of this study was to investigate the safety and efficacy of using the Trabectome as a stand-alone procedure in the treatment of pseudophakic eyes in Chinese open-angle glaucoma (OAG) patients. PATIENTS AND METHODS This was a prospective study conducted at a district hospital in Hong Kong Special Administrative Region China. Subjects had been recruited from a glaucoma subspecialty center. OAG individuals requiring purification operation for IOP control in spite of tolerated antiglaucoma medicines were recruited maximally. The inclusion requirements included: consenting GSK-923295 adults >18 years; open-angle construction of Quality 2 or above in ≥90° on gonioscopy (Shaffer grading) pseudophakia and proof glaucomatous optic neuropathy on optical coherence tomography or Humphrey Visible Field. The exclusion criteria included subject matter with only 1 functional eye and the ones with preexisting corneal scars or pathologies. Publication financing was supplied by Neomedix Company (Tustin CA). The authors had full autonomy over the info write-up and analysis without involvement from the funding source. The Trabectome treatment: Topical anesthesia with xylocaine gel 2% and intracameral lignocaine 2%. The working microscope was tilted to 30° from the cosmetic surgeon as well as the patient’s mind was converted in the contrary direction from the working eye to increase the visualization from the nose angle. A 1.8?mm crystal clear cornea incision temporally was produced. Keeping the Trabectome suggestion in to the Schlemm canal under gonioscopic assistance. 120 ablation was made out of the Trabectome to remove the internal wall structure of Schlemm and trabecular meshwork. Aspiration and Irrigation was GSK-923295 performed to washout any bloodstream reflux. Stromal hydration to close the corneal wound. Intracameral cefuroxime 1?mg in 0.1?mL. Following the treatment all preexisting topical ointment antiglaucoma medicines were continuing. Postoperative medicines consist of pilocarpine 1% 4 moments daily for four weeks topical ointment antibiotic 4 moments daily and topical ointment steroids 4 moments daily for one to two 2 weeks postoperatively. Individuals were seen the entire day time.